FLOT1 knockdown
Intervention1 paper1 finding
- Animals1
Outcomes
1Disabled macroautophagy
downin mouse cells1
1 study
Disabled macroautophagy
downin mouse cells1
FLOT1 knockdown decreases disabled macroautophagy in mouse cells.
“Flot1 knockdown reduced α-Syn internalization, PI3K phosphorylation, autophagy impairment, and lipid accumulation”
Cellsmacrophage
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
Latest
1AnimalsmTOR & rapamycin
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.