Alpha-synuclein
Intervention1 paper2 findingsMeSH D051844
- Animals1
Outcomes
2Autophagy
downin mouse cells1
1 study
Autophagy
downin mouse cells1
Alpha-synuclein inhibits autophagy in mouse cells.
“Mechanistically, α-Syn promoted macrophage foam cell formation by impairing autophagic flux, accompanied by activation of PI3K-mTOR signaling.”
Cellsmacrophage
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
Atherosclerosis
upin mice1
1 study
Atherosclerosis
upin mice1
Alpha-synuclein increases atherosclerosis in mice.
“administration of exogenous α-Syn accelerated atherosclerosis in Apolipoprotein E knockout (Apoe -/- ) mice.”
Animalsin Apolipoprotein E knockout (Apoe -/- ) miceexogenous
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
Latest
1AnimalsmTOR & rapamycin
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.