ENPP1 mutation
Intervention1 paper2 findings
- Animals1
Outcomes
2Exploration
downin mice1
1 study
Exploration
downin mice1
ENPP1 mutation decreases exploration in mice.
Animalsdependent on STINGH362A point mutation
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint
Motor coordination
downin mice1
1 study
Motor coordination
downin mice1
ENPP1 mutation impairs motor coordination in mice.
Animalsdependent on STINGH362A point mutation
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint
Latest
1Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.