CTNNB1 deletion
Intervention1 paper4 findings
- Animals1
Outcomes
2Myeloid cell
downin mice1−79% to −48%
1 study
Myeloid cell
downin mice1−79% to −48%
CTNNB1 deletion decreases myeloid cell in mice (-48%).
Animalspost IVD injuryintervertebral disc
Deleting beta-catenin in mouse disc cells lowers inflammation and immune cell recruitment · Aging cell · 1 Oct 2026
CTNNB1 deletion decreases myeloid cell in mice (-79%).
Animalsnaive IVDintervertebral disc
Deleting beta-catenin in mouse disc cells lowers inflammation and immune cell recruitment · Aging cell · 1 Oct 2026
Ccl2
downin mice1−79% to −58%
1 study
Ccl2
downin mice1−79% to −58%
CTNNB1 deletion decreases Ccl2 in mice (-79%).
AnimalsAcanCreERT2-mediatedAcanCreERT2-mediatedintervertebral discfemales
Deleting beta-catenin in mouse disc cells lowers inflammation and immune cell recruitment · Aging cell · 1 Oct 2026
CTNNB1 deletion decreases Ccl2 in mice (-58%).
AnimalsAcanCreERT2-mediatedAcanCreERT2-mediatedintervertebral discmales
Deleting beta-catenin in mouse disc cells lowers inflammation and immune cell recruitment · Aging cell · 1 Oct 2026
Latest
1Deleting beta-catenin in mouse disc cells lowers inflammation and immune cell recruitment
Simulating age-related declines in disc Wnt signaling blunted chemotactic gene expression and cut injury-induced myeloid infiltration roughly in half.