Tnf
GeneMus musculus4 papersMGI 104798NCBI Gene 21926Taxon 10090
- Animals4
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4AnimalsBrain aging
Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice
The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a persistent transcriptional program.
AnimalsMitochondria
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.