Phosphorylated tau

Biomarker2 papers1 finding

Animals1
Cells1

Interventions

1

Mtdna depletion

downin human cells1

1 study

Mtdna depletion decreases phosphorylated tau in human cells.
Cellschronic mtDNA depletion (rho0)SH-SY5Y
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels · Journal of Alzheimer's disease : JAD · 29 Sep 2026

Mtdna depletion →

Latest

4

HumansBrain aging1 Oct

Speech clocks reflect dementia phenotypes and biological aging markers

A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.

Science Advances · Hernandez H et al.

Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels

CellsJournal of Alzheimer's Disease

30 Sep

AnimalsBrain aging28 Sep

Aging rhesus macaques display distinct fluid proteomic signatures of senescence and neuropathology

Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.

GeroScience · Diniz GB et al.

Blood biomarkers of oxidative stress and mitochondrial dysfunction in Parkinson's disease and Alzheimer's disease

ReviewInternational Review of Neurobiology

26 Sep