GrimAge2
Biomarker2 papers3 findings
- Human trial1
- Humans1
Interventions
1Exercise
downin humans1
1 study
Exercise
downin humans1
Exercise decreases GrimAge2 in humans.
Human trialin breast cancer survivorsremotely deliveredwhole blood12 monthsfemalesn = 124
Exercise slows epigenetic aging in breast cancer survivors · Journal of the National Cancer Institute · 30 Sep 2026
Associations
2Mortality
upin humans1
1 study
Mortality
upin humans1
GrimAge2 is associated with mortality in humans (HRperSD = 1.44-1.62).
Humans16-yearn = 861
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers · Aging cell · 1 Oct 2026
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
GrimAge2 is associated with cognitive function in humans.
Human trialin breast cancer survivorswhole blood12 monthsfemalesn = 124
Exercise slows epigenetic aging in breast cancer survivors · Journal of the National Cancer Institute · 30 Sep 2026
Latest
2Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Exercise slows epigenetic aging in breast cancer survivors
A randomized trial shows a 12-month workout program slowed DNA methylation clocks and linked with preserved cognitive health.