MitochondriaAnimals
Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice
- High-intensity interval training
- Cellular senescence
- Disabled macroautophagy
- Mitochondrial dysfunction
- Telomere attrition
- Autophagy
- Mitochondrial biogenesis (PGC-1α)
- Sirtuin signalling
- p16INK4a–RB pathway
- p53–p21 pathway
- Becn1
- Cdkn1a
The paper
Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice
Seldeen KL, Saha S, Wang B et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences · 25 Sep 2026