Curcumin

1. Curcumin improves cell viability in D. discoideum.

   “All three compounds significantly improved viability and reduced doubling time in 80Q-expressing cells.”

   Model organismsin 80Q-expressing cells

   Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026

1. Curcumin decreases loss of proteostasis in D. discoideum.

   “Thioflavin T (ThT) and Congo Red assays demonstrated a marked reduction in amyloid-like polyQ aggregates following treatment.”

   Model organismsin 80Q-expressing cells

   Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026

Loss of proteostasis →