CD38 inhibitors
Intervention1 paper2 findings
- Animals1
Outcomes
2Fetal growth retardation
downin animals1
1 study
Fetal growth retardation
downin animals1
CD38 inhibitors protect against fetal growth retardation.
Animalsage-associated pregnancy complicationsplacentafemales
Macrophage CD38 drives age-related placental senescence by depleting NAD+ · Nature communications · 27 Aug 2026
Cellular senescence
downin animals1
1 study
Cellular senescence
downin animals1
CD38 inhibitors decrease cellular senescence.
Animalsage-relatedplacentafemales
Macrophage CD38 drives age-related placental senescence by depleting NAD+ · Nature communications · 27 Aug 2026
Latest
1AnimalsNAD+ & sirtuins
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.