usp-48
GeneCaenorhabditis elegans1 paper2 findingsNCBI Gene 172782Taxon 6239
- Model organisms1
Effects
2Mitochondrial unfolded protein response
mediatesin worms1
1 study
Mitochondrial unfolded protein response
mediatesin worms1
usp-48 mediates mitochondrial unfolded protein response in worms.
Model organisms
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms · Cell reports · 30 Sep 2026
Lifespan
is required forin worms1
1 study
Lifespan
is required forin worms1
usp-48 is required for lifespan in worms.
Model organismshypodermis
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms · Cell reports · 30 Sep 2026
Latest
1Model organismsMitochondria
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.