TP53BP1
GeneHomo sapiens3 papers1 findingHGNC 11999NCBI Gene 7158Taxon 9606
- Cells3
Interventions
1Farnesylation amino acid targeted editing
upin human cells1
1 study
Farnesylation amino acid targeted editing
upin human cells1
Farnesylation amino acid targeted editing improves TP53BP1 in human cells.
CellsHGPS NMOsneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026
Latest
3Cells
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
CellsCellular senescence
Loss of adenosine deaminase impairs DNA repair and triggers astrocyte senescence in ALS
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.