Tnfrsf1a
GeneMus musculus1 paper1 findingMGI 1314884NCBI Gene 21937Taxon 10090
- Animals1
Effects
1Platelet
upin mice1
1 study
Platelet
upin mice1
Tnfrsf1a induces platelet in mice.
Animalsindependent of HSPC expansion
Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice · bioRxiv · 29 Sep 2026 · Preprint
Latest
1Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice
The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a persistent transcriptional program.