Polygenic risk score
Biomarker1 paper1 finding
- Humans1
Associations
1Alzheimer's disease and related dementias
upin humans1
1 study
Alzheimer's disease and related dementias
upin humans1
Polygenic risk score predicts Alzheimer's disease and related dementias in humans (sHR = 2.24, 95% CI: 2.02-2.48).
“PRS was the strongest predictor (subdistribution hazard ratio [sHR] = 2.24, 95% CI: 2.02-2.48)”
Humansin UK Biobankmedian 10.08 yearsn = 16,215
Biological aging clocks combined with genetics improve dementia risk prediction · Alzheimer's & dementia : the journal of the Alzheimer's Association · 29 Sep 2026
Latest
2Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
HumansBrain aging
Biological aging clocks combined with genetics improve dementia risk prediction
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.