ASXL1 mutation
Biomarker1 paper2 findings
- Humans1
Associations
2Smoking
upin humans1
1 study
Smoking
upin humans1
Smoking is associated with ASXL1 mutation in humans.
Humans
Clonal blood mutations in ASXL1 associate with higher lung cancer risk · Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 28 Sep 2026
Lung cancer
upin humans1
1 study
Lung cancer
upin humans1
ASXL1 mutation raises the risk of lung cancer in humans (hazard ratio = 3.2).
Humanshigh variant allele fraction (high-VAF), adjusted for age, sex, BMI, smoking status, and genetic ancestry
Clonal blood mutations in ASXL1 associate with higher lung cancer risk · Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 28 Sep 2026
Latest
1Clonal blood mutations in ASXL1 associate with higher lung cancer risk
Researchers analyzing two large human cohorts found that ASXL1-mutant clonal hematopoiesis linked to more than triple the risk of lung cancer in smokers.