Brain age
Biomarker2 papers1 finding
- Humans2
Associations
1Schizophrenia
upin humans1
1 study
Schizophrenia
upin humans1
Schizophrenia is associated with brain age in humans.
Humansin patients with glymphatic impairmentbrain
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia · bioRxiv · 30 Sep 2026 · Preprint
Latest
19Neural stem cell exhaustion disrupts central nervous system renewal in aging colonial chordates
Researchers identified a conserved neural progenitor pool that drives weekly brain regeneration in Botryllus schlosseri but collapses during aging.
Aging mouse brains accumulate myelin lipids that drive lysosomal dysfunction
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Brain cells organize into distinct DNA repair niches during mouse aging
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
Compartment-resolved brain aging reveals distinct vascular and neurodegenerative pathways
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.
Human neurons accumulate far more mutations over lifespan than shorter-lived mammals
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.