ReviewPeer-reviewed

Wound Healing, Senescence, and Senotherapeutics

Advances in wound care · 30 Sept · Pitcher LE, Zhu J, Schmidt EL et al.

The paper

Pitcher LE, Zhu J, Schmidt EL et al.

Advances in wound care

doi.org/10.1177/21621918261490101

Our read

Relevance: Core geroscience
Newsworthiness: Routine
Evidence: Review
Status: Peer-reviewed
Topic: Cellular senescence

Human trialPeer-reviewed

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.

Cellular senescence

AnimalsPreprint

A distinct p21-driven macrophage senotype accumulates during aging and liver disease

Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.

bioRxiv · 28 Sept · Torres G, Salladay-Perez IA, Deng CY et al.

Cellular senescence

HumansPreprint

DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.

Cellular senescence

AnimalsPeer-reviewed

Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates

Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.

Aging cell · 1 Oct · Deng J, Zeng X, Guo J et al.

Cellular senescence

Human trialPeer-reviewed

A deep learning score for cellular senescence predicts human mortality and disease risk

The proteomic biomarker tracked chronic illness risk in the UK Biobank and shifted following an 18-month multimodal exercise intervention.

Aging cell · 1 Oct · Zhao S, Kuo CL, Lenze EJ et al.

Cellular senescence