Model organisms
Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes
The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans.
Search results for reactive oxygen species
113 results
Dietary restriction activates autophagy through selective oxidation of ATG5
Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.
- AnimalsCellular senescence
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
- AnimalsCellular senescence
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.
- Animals
A magnesium-phenolic hydrogel accelerates wound healing in aged mice
The engineered dressing scavenges reactive oxygen species, shifts immune cells toward repair, and promotes blood vessel formation to improve tissue regeneration in senescent skin.
- AnimalsInflammaging
Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging
Vesicles fused from M2 macrophages and keratinocytes reduced oxidative stress, inflammation, and collagen degradation through the IL-4Rα/JAK/STAT3 pathway.
- AnimalsMitochondria
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.