Review
The Meiotic Spindle, Mechanisms of Chromosome Segregation and Aneuploidy in Aging Human Oocytes: An Update Review
Abstract · CC BY
The meiotic spindle is essential for accurate chromosome segregation during oocyte maturation and fertilization, and its alteration might be considered a major contributor to age-related aneuploidy and reproductive failure.
- Genomic instability
- Mitochondrial dysfunction
- Congenital disorders
- Implantation failure
- Infertility
- Recurrent pregnancy loss
- Homo sapiens
The paper
The Meiotic Spindle, Mechanisms of Chromosome Segregation and Aneuploidy in Aging Human Oocytes: An Update Review
Sciorio R, Teglas G, Tramontano L et al.
Medicina · 20 Sep 2026