Abstract · CC BY
Aging is a gradual process of structural and functional decline, marked by erosion of physiological integrity, adaptive capacity, and resilience, and by a concomitant increase in vulnerability to disease, disability, and death.
The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation
Chmielewski PP, Strzelec B
International Journal of Molecular Sciences · 11 Sep 2026
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.
Overexpressing the noncoding RNA restored bone healing in mice, separating impaired osteogenesis from the onset of cellular senescence.
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
