Cellular senescenceReview26 Sep 2026

Conditional Senescence and Longevity Mechanisms in Early-Branching Metazoans: Insights from Hydra

Current Issues in Molecular Biology

Abstract · CC BY

Organismal aging is not inevitable in multicellular animals, as early-branching metazoan lineages, such as cnidarians, display negligible senescence under defined conditions, despite conserved cellular pathways. Contrasting longevity phenotypes in Hydra species reveal distinct regulatory mechanisms underlying aging.

The paper

Russo V, Udroiu I, Cianfanelli V et al.

Current Issues in Molecular Biology · 19 Sep 2026

doi.org/10.3390/cimb48090956 PubMed

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The paper

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