MitochondriaCells
Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors
Abstract · CC BY
Background/Objectives: Osteoarthritis (OA) is strongly associated with mitochondrial dysfunction, oxidative stress, and the accumulation of mitochondrial DNA (mtDNA) alterations in several joint-associated cell types, including chondrocytes, synoviocytes, and mesenchymal stromal cells (MSCs).
- Genomic instability
- Mitochondrial dysfunction
- Stem cell exhaustion
- Oxidative phosphorylation
- Oxidative stress and ROS signalling
- MEG3
- MT-ATP8
- MT-CO1
- MT-ND1
- MT-RNR1
- SNHG14
- Osteoarthritis
The paper
Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors
Konteles V, Papathanasiou I, Tzetis M et al.
Genes · 11 Sep 2026