Vegfa deletion
Intervention1 paper2 findings
- Animals1
Outcomes
2Aqueous humor outflow facility
downin mice1
1 study
Aqueous humor outflow facility
downin mice1
Vegfa deletion decreases aqueous humor outflow facility in mice.
Animalsin CX3CR1+ macrophagesCX3CR1-Cre driven conditional knockoutocular angle
Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint
Intraocular pressure
upin mice1
1 study
Intraocular pressure
upin mice1
Vegfa deletion increases intraocular pressure in mice.
Animalsin CX3CR1+ macrophagesCX3CR1-Cre driven conditional knockoutocular angle
Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint
Latest
1Macrophage-derived VEGFA helps maintain eye fluid pressure during aging
In aged mice and humans, macrophages cluster near Schlemm's canal to preserve aqueous humor outflow through compensatory growth factor signaling.