Tfam knockdown
Intervention1 paper3 findings
- Animals1
Outcomes
3Heterosubtypic recall immunity
downin mice1
1 study
Heterosubtypic recall immunity
downin mice1
Tfam knockdown impairs heterosubtypic recall immunity in mice.
Animalsfollowing influenza infection
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Viral pneumonia
upin mice1
1 study
Viral pneumonia
upin mice1
Tfam knockdown increases viral pneumonia in mice.
Animalsinfluenza infectionlung
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Mitochondrial dysfunction
upin mice1
1 study
Mitochondrial dysfunction
upin mice1
Tfam knockdown induces mitochondrial dysfunction in mice.
AnimalsCD8+ T cell-specific haploinsufficiencyCD8-positive, alpha-beta T cell
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint
Latest
1TFAM deficiency in T cells worsens viral lung pathology and weakens immunity
Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.