Prevention of hira sumoylation
Intervention1 paper3 findings
- Animals1
Outcomes
3Preimplantation development rate
upin mice1
1 study
Preimplantation development rate
upin mice1
Prevention of hira sumoylation improves preimplantation development rate in mice.
Animalsin aged oocytesoocytefemales
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality · bioRxiv · 29 Sep 2026 · Preprint
Oocyte maturation
upin mice1
1 study
Oocyte maturation
upin mice1
Prevention of hira sumoylation improves oocyte maturation in mice.
Animalsin aged oocytesoocytefemales
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality · bioRxiv · 29 Sep 2026 · Preprint
H3-3a
upin mice1
1 study
H3-3a
upin mice1
Prevention of hira sumoylation increases H3-3a in mice.
Animalsin aged oocytesoocytefemales
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality · bioRxiv · 29 Sep 2026 · Preprint
Latest
1Restoring HIRA chromatin maintenance improves aged mouse oocyte quality
Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.