PNPLA7 knockout
Intervention1 paper3 findings
- Animals1
Outcomes
3Glycerophosphocholine
downin mouse cells1
1 study
Glycerophosphocholine
downin mouse cells1
PNPLA7 knockout inhibits glycerophosphocholine in mouse cells.
Cellsmyoblasts
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026
Cardiolipin
downin mice1
1 study
Cardiolipin
downin mice1
PNPLA7 knockout decreases cardiolipin in mice.
Animalsglobal deficiencyskeletal muscle
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026
Physical function
downin mice1
1 study
Physical function
downin mice1
PNPLA7 knockout impairs physical function in mice.
Animalsglobal deficiencyquadriceps
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026
Latest
1Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.