Cardiolipin
Biomarker2 papers1 finding
- Animals2
Interventions
1PNPLA7 knockout
downin mice1
1 study
PNPLA7 knockout
downin mice1
PNPLA7 knockout decreases cardiolipin in mice.
Animalsglobal deficiencyskeletal muscle
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026
Latest
3AnimalsMitochondria
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
AnimalsMitochondria
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.