Localized scleroderma
Disease1 paper1 finding
- Animals1
Interventions
1Parthenolide
downin mice1
1 study
Parthenolide
downin mice1
Parthenolide protects against localized scleroderma in mice.
AnimalsF127@PLGA@PTL hydrogel
Parthenolide reduces senescence and skin fibrosis in scleroderma models · Aging cell · 30 Sep 2026
Latest
1AnimalsMitochondria
Parthenolide reduces senescence and skin fibrosis in scleroderma models
The compound targets Ero1L to stabilize contacts between mitochondria and the endoplasmic reticulum, mitigating tissue damage in cells and mice.