Sphingomyelin
Biomarker1 paper
- Cells1
Latest
3CellsPreprint
Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
AnimalsBrain aging
Aging mouse brains accumulate myelin lipids that drive lysosomal dysfunction
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease
A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.