Lipid droplets
Biomarker1 paper1 finding
- Model organisms1
Upstream
1sex-1
downin worms1
1 study
sex-1
downin worms1
sex-1 decreases lipid droplets in worms.
Model organismsneuron
A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria · bioRxiv · 29 Sep 2026 · Preprint
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4A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria
Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity declines with age.
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.