Frailty index
Biomarker2 papers1 finding
- Humans2
Associations
1Epigenetic alterations
mixedin humans1
1 study
Epigenetic alterations
mixedin humans1
Frailty index is associated with epigenetic alterations in humans (448 differentially methylated regions and 488 differentially variable regions).
Humansbloodn = 1,445
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity · bioRxiv : the preprint server for biology · 25 Sep 2026 · Preprint
Latest
3DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
High metabolic inflammation trajectories predict faster frailty progression in older adults
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts.
Machine learning frailty index from healthcare claims predicts mortality and disability
Integrating diagnoses, medications, and procedures into a 63-item tool outperformed an established multimorbidity index in adults aged 50 and older.