Saturday, 3 October 2026
The river
Every paper about the biology of aging, newest first, as it arrives.
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
Food science & nutrition · Shi H et al.
Culturing human neural, cardiac, and tonsil models in rotating-wall vessels for 24 hours also shifted contraction dynamics and immune gene expression.
bioRxiv · Mu W-C et al.
A percentile-based normalization method reveals substrate preferences between proteasomal and lysosomal clearance systems in cultured cells.
bioRxiv · Gao Z et al.
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Frontiers in pharmacology · Yang K et al.
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
bioRxiv · Yeewa R et al.
A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle mass, grip strength, and walking pace.
Medicine · Mei Z et al.
Extended larval periods lowered lifetime reproductive success in Bugula neritina but reduced the rate of actuarial senescence in the field.
Evolution letters · Morgan W et al.
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
bioRxiv : the preprint server for biology · Liu J et al.
Epicutaneous challenges in mice reveal context-dependent shifts in local immune cell recruitment rather than a uniform decline in tissue immunity.
bioRxiv : the preprint server for biology · Severn MM et al.
Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.
Journal of neurochemistry · Nicol NI et al.
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
bioRxiv · Olova NN et al.
A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.
bioRxiv : the preprint server for biology · Badillo S et al.
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
bioRxiv · R. Carvalho D et al.
Aged male mice showed far larger proteomic shifts than females following microglial removal, including alterations in synaptic and mitochondrial proteins.
bioRxiv : the preprint server for biology · Beganovic A et al.
Transient overexpression of the retrotransposon alters gene expression, proteins, and secretions while affecting cell cycle and interferon pathways.
bioRxiv : the preprint server for biology · Bravo JI et al.
Researchers identified a conserved neural progenitor pool that drives weekly brain regeneration in Botryllus schlosseri but collapses during aging.
bioRxiv : the preprint server for biology · Anselmi C et al.
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
bioRxiv : the preprint server for biology · Skiles CM et al.
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
bioRxiv : the preprint server for biology · Son W et al.
Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.
bioRxiv : the preprint server for biology · Correia J et al.
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
bioRxiv : the preprint server for biology · Vishnyakova O et al.
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Cell reports · Sarkar C et al.
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
bioRxiv : the preprint server for biology · Koshboresh A et al.
Researchers identified a transient senescent-like monocyte state governed by the transcription factor AP-1 that primes cells toward inflammatory and sepsis-associated states.
bioRxiv : the preprint server for biology · Vasilopoulos T et al.
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
bioRxiv : the preprint server for biology · McCarthy EC et al.
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
bioRxiv : the preprint server for biology · Bidhan V et al.
In aged mice and humans, macrophages cluster near Schlemm's canal to preserve aqueous humor outflow through compensatory growth factor signaling.
bioRxiv : the preprint server for biology · Kiyota N et al.
Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.
Science advances · Wang B et al.
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.
Research square · Kim H et al.
In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.
bioRxiv : the preprint server for biology · Chen M et al.
Shear wave elastography and transcriptomic profiling show that ovarian fibrosis correlates with reduced oocyte yield and follicular efficiency.
Research square · Duncan F et al.
Male mice experience greater distal axon withdrawal that can be reversed by targeting muscle niches with nerve growth factor.
bioRxiv : the preprint server for biology · Pangilinan GR et al.
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
bioRxiv : the preprint server for biology · Hughes L et al.
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.
bioRxiv : the preprint server for biology · Joshi V et al.
Reducing dietary cysteine independently of methionine enhanced survival in nematodes and reprogrammed the immunometabolic axis in mice.
bioRxiv : the preprint server for biology · Orliaguet L et al.
Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.
medRxiv : the preprint server for health sciences · Harris KC et al.
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
bioRxiv : the preprint server for biology · Boldridge MA et al.
A large genomic analysis reveals over 800 inherited variants and structural features that alter how frequently chromosomes missegregate in aging individuals.
medRxiv : the preprint server for health sciences · Si Y et al.
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.
bioRxiv : the preprint server for biology · Caglayan E et al.