SATB1 deletion

Intervention1 paper1 finding

Animals1

Outcomes

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Epigenetic alterations

upin mice1

1 study

SATB1 deletion induces epigenetic alterations in mice.
Animalsin naive T cellsconditional knockoutnaive CD4+ T cell
Loss of SATB1 alters 3D genome architecture in aged mouse T cells · Science advances · 2 Oct 2026

Epigenetic alterations →

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AnimalsInflammagingYesterday

Loss of SATB1 alters 3D genome architecture in aged mouse T cells

Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.

Science Advances · Wang B et al.