PIEZO1 deletion
Intervention1 paper2 findings
- Animals1
Outcomes
2Gastrointestinal motility disorder
downin mice1
1 study
Gastrointestinal motility disorder
downin mice1
PIEZO1 deletion prevents gastrointestinal motility disorder in mice.
Animalssmooth muscle Piezo1 deletion in aginggut
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint
Physical function
upin mice1
1 study
Physical function
upin mice1
PIEZO1 deletion improves physical function in mice.
Animalsinducible smooth muscle cell-specific deletioninducible smooth muscle cell-specificgut
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint
Latest
1Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.