Gastrointestinal motility disorder
Disease1 paper1 finding
- Animals1
Interventions
1PIEZO1 deletion
downin mice1
1 study
PIEZO1 deletion
downin mice1
PIEZO1 deletion prevents gastrointestinal motility disorder in mice.
Animalssmooth muscle Piezo1 deletion in aginggut
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint
Latest
1AnimalsPreprint
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.