Mitochondrial mutagenesis induction
Intervention1 paper1 finding
- Animals1
Outcomes
1Age-related pathology
upin mice1
1 study
Age-related pathology
upin mice1
Mitochondrial mutagenesis induction induces age-related pathology in mice.
Animalsconfined to the first two months of lifetwo months
Early-life mitochondrial DNA mutations drive age-related pathology in mice · bioRxiv · 27 Sep 2026 · Preprint
Latest
1Early-life mitochondrial DNA mutations drive age-related pathology in mice
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.