HCAR1 knockout
Intervention1 paper1 finding
- Animals1
Outcomes
1Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
HCAR1 knockout induces cellular senescence in mice.
Animalsendothelial-specific deletion in young miceendothelial-specific deletionendothelial cell
Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint
Latest
1Lactate receptor activation reduces cellular senescence and protects vascular health in mice
Loss of the lactate receptor GPR81 drives arterial senescence and lipid accumulation, while pharmacological stimulation restores vascular homeostasis in progeroid mice.