p16INK4a
Biomarker2 papers
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4DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence
Physical activity preserved cardiac function and sustained FNDC5 and irisin signaling in mice exposed to doxorubicin.
Cells
Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells
Vesicles from melatonin-treated stem cells targeted SRSF1 and SP1 to lower progerin and cellular prion protein in cell models.
CellsCellular senescence
Loss of adenosine deaminase impairs DNA repair and triggers astrocyte senescence in ALS
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.