H3K9me2
Biomarker1 paper1 finding
- Cells1
Interventions
1NPM1 knockdown
downin human cells1
1 study
NPM1 knockdown
downin human cells1
NPM1 knockdown decreases H3K9me2 in human cells.
Cellsat relocated LADsdepletion
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint
Latest
1CellsPreprint
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.