Biological age
Biomarker1 paper
- Humans1
Latest
40Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Somatic blood mutations associate with accelerated frailty and functional decline in humans
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
Mechanistic biological age clock matches PhenoAge in predicting human mortality
The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.
Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
Organ age acceleration and mortality risk reflect distinct biological processes
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
Dietary iron links to slower biological aging while high supplement doses accelerate it
An analysis of NHANES data identifies source-dependent effects and an optimal serum iron window between 15.2 and 18.8 micromoles per liter.
Accelerated biological aging links to higher gout risk and increased mortality
Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.