Amyloid
Biomarker1 paper1 finding
- In silico1
Associations
1Brain age gap
mixedin silico1
1 study
Brain age gap
mixedin silico1
Amyloid is associated with brain age gap in silico (83.2% with the leading eigenvector versus a maximal value of 7.7% for any brain region).
“eigenspectrum of the anatomical covariance matrix explains the different longitudinal effects observed in brain age gap in amyloid positive vs amyloid negative subcohorts more prominently than individual brain regions”
In silicoin Mild Cognitive Impairment (MCI)brain
Covariance Eigenspace Provides Latent Attribution of Longitudinal Effects in Brain Age Gap · arXiv · 30 Sep 2026 · Preprint
Latest
25Compartment-resolved brain aging reveals distinct vascular and neurodegenerative pathways
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.