TrialCompleted
Biomarkers, Abdominal Muscle, and Frailty in CKD
The Association of Total Oxidant/Antioxidant Capacity and MCP-1 Markers With Abdominal Muscle Thickness and Frailty in Patients With Stage 3-5 Chronic Kidney Disease
- Sponsor
- Ankara City Hospital Bilkent (Academic or other)
- Enrolment
- 88 enrolled
- Conditions
- Chronic Kidney Disease; Abdominal Muscles/Ultrasonography; Frailty
- Interventions
- total antioxidant status; total oxidant status; monocyte chemotactic protein-1; ultrasonography muscle; FRAIL scale; clinical frailty scale; tampa scale
- Ages
- adults, older adults
- Registry
- NCT07854275
From the registry
In chronic kidney disease (CKD), inflammation and oxidative stress are important processes that may be associated with the development of muscle loss and frailty. The aim of this study is to investigate the relationships between serum MCP-1, total antioxidant status (TAS), and total oxidant status (TOS)-markers of inflammation and oxidative stress-and abdominal muscle thickness and frailty, as assessed by ultrasound, in stage 3-5 CKD patients not receiving dialysis. In addition, the study aims to assess participants' physical performance, kinesiophobia, and quality of life and to examine these characteristics according to CKD stages.
Primary outcomes
- Ultrasonography measurements
- Frailty
- Frailty 2
- total antioxidant status