Caloric restriction and neuropsychiatric phenotypes: A critical review of preclinical data
Anousi E, Filiou MD
Neuroscience and Biobehavioral Reviews · 26 Sep 2026
Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.
Reducing dietary cysteine independently of methionine enhanced survival in nematodes and reprogrammed the immunometabolic axis in mice.
Nitric oxide produced by hepatocytes during fasting blocks autophagy in stellate cells to halt fibrotic progression in mice.
Researchers found that dietary restriction reshapes alternative splicing in an age-specific manner while driving coordinated changes in cortical brain lipids.
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
