Transcriptomic age
Biomarker2 papers2 findings
- Animals1
- Cells1
Interventions
2Simulated microgravity
upin human cells1
1 study
Simulated microgravity
upin human cells1
Simulated microgravity increases transcriptomic age in human cells.
“accompanied by higher transcriptomic-age estimates in neural and cardiac models”
Cellsin rotating-wall vesselsrotating-wall vesselscardiac organoids24 hours
Simulated microgravity increases transcriptomic age in human organoids · bioRxiv · 1 Oct 2026 · Preprint
NKX2-5 overexpression
downin mouse cells1
1 study
NKX2-5 overexpression
downin mouse cells1
NKX2-5 overexpression decreases transcriptomic age in mouse cells.
Cells
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Latest
3Simulated microgravity increases transcriptomic age in human organoids
Culturing human neural, cardiac, and tonsil models in rotating-wall vessels for 24 hours also shifted contraction dynamics and immune gene expression.
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.
Blood and facial photos track organ aging and senescence scores in humans
Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark burdens.