Autophagy flux
Biomarker1 paper2 findings
- Humans1
Interventions
1Exercise
downin humans1
1 study
Exercise
downin humans1
Exercise decreases autophagy flux in humans.
“In a pilot intervention study, PBMC autophagy flux decreased following 12 weeks of mild exercise in parallel with improved physical function”
Human trialmild exerciseperipheral blood mononuclear cell12 weeks
Autophagy flux varies by sex and cell type during human aging · Aging cell · 28 Sep 2026
Associations
1Physical function
downin humans1
1 study
Physical function
downin humans1
Autophagy flux is associated with physical function in humans.
“in adults aged > 70 years, higher autophagy flux was associated with reduced physical function.”
Humans
Autophagy flux varies by sex and cell type during human aging · Aging cell · 28 Sep 2026
Latest
2Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
Humans
Autophagy flux varies by sex and cell type during human aging
In older adults, higher autophagy flux in blood cells linked to lower physical function and decreased after a 12-week exercise intervention.