Model organismsPeer-reviewed

Transgenerational and Intergenerational Maternal Age Effects Exhibit Complex, Genotype-Specific Patterns of Inheritance

The American naturalist · 5 May · Liguori A, Korm S, Profetto A et al.

The paper

Liguori A, Korm S, Profetto A et al.

The American naturalist

doi.org/10.1086/742104

Our read

Relevance: Core geroscience
Newsworthiness: Notable
Evidence: Model organisms
Status: Peer-reviewed

CellsPreprint

Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways

Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.

bioRxiv · 30 Sept · Grafton F, Rohani N, Lim WF et al.

AnimalsPreprint

Engineered cardiac transcription factor restores vision and reduces frailty in aging mice

A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.

bioRxiv · 30 Sept · Lu YRR, Shen H, Kajderowicz K et al.

CellsPeer-reviewed

Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids

Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.

Nature communications · 31 Aug · Kim DW, Kwon EJ, Jeon BJ et al.

HumansPeer-reviewed

Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment

Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.

Nature immunology · 30 Sept · Aguilar-Navarro AG, Edun G, Gower M et al.

Model organismsPreprint

Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes

A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.

bioRxiv · 30 Sept · Judson KL, Danielson KJ, Tang S et al.